ASXLS BINDING TO THE PHD2/3 FINGERS OF MLL4 PROVIDES A MECHANISM FOR THE RECRUITMENT OF BAP1 TO ACTIVE ENHANCERS

ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers

Abstract The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer.MLL4 glassware and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers.Here, we report a novel function of the PHD2 and PHD3 (PHD2/3) fingers of MLL4 and MLL3 that bind to ASXL2, a component of

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National Variations in the Work-Up, Investigation, and Surgical Management of Ductal Carcinoma In Situ of the Breast across Canadian Surgeons

Variation in the management of Ductal Carcinoma In Situ (DCIS) of the breast occur at both national and international levels.The aim of this study is to determine the degree of, and reasons behind, this variation in the workup HEAVY METAL DETOX and treatment of DCIS among Canadian surgeons.We developed a 35-question survey involving the pre-, peri,

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Comparison Between Photoactivity of ZnO/NiO Nanostructures Synthesized by CBD and Modified -CBD for Rhodamine B Removal

This work describes a comparative study on zinc oxide/nickel oxide (ZnO/NiO) nanostructures deposited on glass substrates by chemical bath Electric Drain Pump and modified bath, (CBD), and (M-CBD) techniques.The photoactivity of ZnO/NiO nanostructure films was tested on Rhodamine B (RB) dye under sunlight.The nanostructure films were evaluated usin

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The Impact of Bureaucratic Reform Policy on Public Services at the Population and Civil Registration Service of North Padang Lawas Regency

Based on an analysis of the bureaucratic conditions in North Padang Lawas Regency after more than 15 years as a new autonomous region, it appears that the quality of public services is still low.The evaluation of the Indonesian Ombudsman Representative for North Sumatra in 2021 placed the district in the "bad" category.Research using qualitative mo

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